4IXC
Crystal structure of Human Glucokinase in complex with a small molecule activator.
Summary for 4IXC
Entry DOI | 10.2210/pdb4ixc/pdb |
Descriptor | Glucokinase isoform 3, SODIUM ION, alpha-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | allosteric regulation, binding sites, catalytic domain, diabetes mellitus, type 2, enzyme activators, glucokinase, hexokinase, humans, models, molecular, mutation, protein conformation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 51478.73 |
Authors | Ogg, D.J.,Hargreaves, D.,Gerhardt, S. (deposition date: 2013-01-25, release date: 2013-04-24, Last modification date: 2020-07-29) |
Primary citation | Waring, M.J.,Bennett, S.N.L.,Boyd, S.,Campbell, L.,Davies, R.D.M.,Gerhardt, S.,Hargreaves, D.,G Martin, N.,Robb, G.R.,Wilkinson, G. Matched triplicate design sets in the optimisation of glucokinase activators maximising medicinal chemistry information content To be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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