4IXC
Crystal structure of Human Glucokinase in complex with a small molecule activator.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucokinase isoform 3 | polymer | 456 | 50807.7 | 1 | UniProt (P35557) Pfam (PF00349) Pfam (PF03727) | Homo sapiens (human) | Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D |
| 2 | B (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 3 | C (A) | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
| 4 | D (A) | (2S)-2-{[1-(3-chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(5-methylpyridin-2-yl)-3-(propan-2-yloxy)propanamide | non-polymer | 467.9 | 1 | Chemie (1JD) | |||
| 5 | E (A) | water | water | 18.0 | 252 | Chemie (HOH) |
Sequence modifications
A: 13 - 465 (UniProt: P35557)
| PDB | External Database | Details |
|---|---|---|
| Gly 10 | - | expression tag |
| Ser 11 | - | expression tag |
| Ser 12 | - | expression tag |
| Ala 27 | Glu 27 | engineered mutation |
| Ala 28 | Glu 28 | engineered mutation |
| Ala 51 | Glu 51 | engineered mutation |
| Ala 52 | Glu 52 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 50807.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 671.1 | |
| All* | Total formula weight | 51478.7 |
