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4IWZ

structure of hCAII in complex with an acetazolamide derivative

Summary for 4IWZ
Entry DOI10.2210/pdb4iwz/pdb
DescriptorCarbonic anhydrase 2, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-2-(thiophen-2-yl)acetamide, ZINC ION, ... (6 entities in total)
Functional Keywordsalpha beta fold, reversible hydration of carbon di oxide to bicarbonate and proton, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P00918
Total number of polymer chains1
Total formula weight29656.83
Authors
Biswas, S.,McKenna, R. (deposition date: 2013-01-24, release date: 2013-12-11, Last modification date: 2024-02-28)
Primary citationBiswas, S.,McKenna, R.,Supuran, C.T.
Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.
Bioorg.Med.Chem.Lett., 23:5646-5649, 2013
Cited by
PubMed: 23993330
DOI: 10.1016/j.bmcl.2013.08.019
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.598 Å)
Structure validation

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