4IW0

Crystal structure and mechanism of activation of TBK1

Summary for 4IW0

Entry DOI	10.2210/pdb4iw0/pdb
Related	4IWO 4IWP 4IWQ
Descriptor	Serine/threonine-protein kinase TBK1, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide (2 entities in total)
Functional Keywords	kinase, atp binding, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9UHD2
Total number of polymer chains	1
Total formula weight	76437.06
Authors	Larabi, A.,Devos, J.M.,Ng, S.-L.,Nanao, M.H.,Round, A.,Maniatis, T.,Panne, D. (deposition date: 2013-01-23, release date: 2013-03-13, Last modification date: 2013-05-22)
Primary citation	Larabi, A.,Devos, J.M.,Ng, S.L.,Nanao, M.H.,Round, A.,Maniatis, T.,Panne, D. Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Rep, 3:734-746, 2013 Cited by PubMed: 23453971 DOI: 10.1016/j.celrep.2013.01.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4 Å)

Structure validation