4IW0
Crystal structure and mechanism of activation of TBK1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase TBK1 | polymer | 658 | 75845.6 | 1 | UniProt (Q9UHD2) Pfam (PF00069) Pfam (PF18396) Pfam (PF18394) | Homo sapiens (human) | NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1 |
| 2 | B (A) | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | non-polymer | 591.5 | 1 | Chemie (BX7) |
Sequence modifications
A: 2 - 657 (UniProt: Q9UHD2)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Asn 135 | Asp 135 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 75845.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 591.5 | |
| All* | Total formula weight | 76437.1 |
