4IUM

Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin

4IUM の概要

• エントリーDOI: 10.2210/pdb4ium/pdb
• 分子名称: papain-like protease 2, Ubiquitin, ZINC ION, ... (5 entities in total)
• 機能のキーワード: viral ovarian tumor domain (otu) protease, deubiquitinase, hydrolase-protein binding complex, hydrolase/protein binding
• 由来する生物種: Equine arteritis virus (EAV); 詳細
• 細胞内の位置: Nsp1 papain-like cysteine proteinase: Host nucleus. Nsp2 cysteine proteinase: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 5-6-7: Host membrane; Multi-pass membrane protein (Potential). 3C-like serine proteinase: Host cytoplasm (Potential). RNA-directed RNA polymerase: Host cytoplasm, host perinuclear region (Potential). Helicase: Host cytoplasm, host perinuclear region (Potential): P19811; Ubiquitin: Cytoplasm (By similarity): P0CG48
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24044.80

構造登録者

Bailey-Elkin, B.A.,James, T.W.,Mark, B.L. (登録日: 2013-01-21, 公開日: 2013-02-13, 最終更新日: 2013-03-20)

• 主引用文献: van Kasteren, P.B.,Bailey-Elkin, B.A.,James, T.W.,Ninaber, D.K.,Beugeling, C.,Khajehpour, M.,Snijder, E.J.,Mark, B.L.,Kikkert, M.; Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.; Proc.Natl.Acad.Sci.USA, 110:E838-E847, 2013; PubMed: 23401522; DOI: 10.1073/pnas.1218464110

実験手法

X-RAY DIFFRACTION (1.45 Å)