4IU6

Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1

Summary for 4IU6

Entry DOI	10.2210/pdb4iu6/pdb
Related	2G6P 4HXX
Descriptor	Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	metap1, methionine aminopeptidase 1, methionine aminopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	43805.38
Authors	Gabelli, S.B.,Zhang, F.,Miller, M.,Liu, J.,Amzel, L.M. (deposition date: 2013-01-19, release date: 2013-05-01, Last modification date: 2024-02-28)
Primary citation	Zhang, F.,Bhat, S.,Gabelli, S.B.,Chen, X.,Miller, M.S.,Nacev, B.A.,Cheng, Y.L.,Meyers, D.J.,Tenney, K.,Shim, J.S.,Crews, P.,Amzel, L.M.,Ma, D.,Liu, J.O. Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J.Med.Chem., 56:3996-4016, 2013 Cited by PubMed: 23634668 DOI: 10.1021/jm400227z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation