Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution

Summary for 4ITM

Related4EHW 4EHX 4EHY
DescriptorTetraacyldisaccharide 4'-kinase, ADENOSINE-5'-TRIPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total)
Functional Keywordsmembrane protein, kinase, lipid a, p-loop, p-loop containing nucleoside triphosphate hydrolase, disaccharide-1-phosphate 4'-kinase, membrane, transferase, ipid metabolism, tetraacyldisaccharide 4'-kinase
Biological sourceAquifex aeolicus
Total number of polymer chains1
Total molecular weight37553.48
Emptage, R.P.,Pemble IV, C.W.,York, J.D.,Raetz, C.R.H.,Zhou, P. (deposition date: 2013-01-18, release date: 2013-04-03, Last modification date: 2017-11-15)
Primary citation
Emptage, R.P.,Pemble, C.W.,York, J.D.,Raetz, C.R.,Zhou, P.
Mechanistic Characterization of the Tetraacyldisaccharide-1-phosphate 4'-Kinase LpxK Involved in Lipid A Biosynthesis.
Biochemistry, 52:2280-2290, 2013
PubMed: 23464738 (PDB entries with the same primary citation)
DOI: 10.1021/bi400097z
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.214301.8%6.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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