4ITD

Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation

Summary for 4ITD

• Entry DOI: 10.2210/pdb4itd/pdb
• Related: 4IJ0
• Descriptor: DNA (5'-D(*CP*GP*CP*GP*(C6G)P*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ... (4 entities in total)
• Functional Keywords: damaged dna, o6-carboxymethylguanine, mutagenesis, dna
• Total number of polymer chains: 2
• Total formula weight: 7923.66

Authors

Zhang, F.,Suzuki, K.,Tsunoda, M.,Wilkinson, O.,Millington, C.L.,Williams, D.M.,Morishita, E.C.,Takenaka, A. (deposition date: 2013-01-18, release date: 2013-05-08, Last modification date: 2024-03-20)

• Primary citation: Zhang, F.,Tsunoda, M.,Suzuki, K.,Kikuchi, Y.,Wilkinson, O.,Millington, C.L.,Margison, G.P.,Williams, D.M.,Czarina Morishita, E.,Takenaka, A.; Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations; Nucleic Acids Res., 41:5524-5532, 2013; PubMed: 23580550; DOI: 10.1093/nar/gkt198

Experimental method

X-RAY DIFFRACTION (1.94 Å)