4ISI

Structure of FACTOR VIIA in complex with the inhibitor (6S)-N-(4-CARBAMIMIDOYLBENZYL)-1-CHLORO-3-(CYCLOBUTYLAMINO)-8,8-DIETHYL-4-OXO-4,6,7,8-TETRAHYDROPYRROLO[1,2-A]PYRAZINE-6-CARBOXAMIDE

4ISI の概要

• エントリーDOI: 10.2210/pdb4isi/pdb
• 関連するPDBエントリー: 4ISH
• 分子名称: Factor VII heavy chain, Factor VII light chain, (6S)-N-(4-carbamimidoylbenzyl)-1-chloro-3-(cyclobutylamino)-8,8-diethyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamide, ... (5 entities in total)
• 機能のキーワード: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P08709 P08709
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34645.16

構造登録者

Wei, A. (登録日: 2013-01-16, 公開日: 2013-02-27, 最終更新日: 2013-03-06)

• 主引用文献: Zhang, X.,Glunz, P.W.,Jiang, W.,Schmitt, A.,Newman, M.,Barbera, F.A.,Bozarth, J.M.,Rendina, A.R.,Wei, A.,Wen, X.,Rossi, K.A.,Luettgen, J.M.,Wong, P.C.,Knabb, R.M.,Wexler, R.R.,Scott Priestley, E.; Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors.; Bioorg.Med.Chem.Lett., 23:1604-1607, 2013; PubMed: 23416003; DOI: 10.1016/j.bmcl.2013.01.094

実験手法

X-RAY DIFFRACTION (1.94 Å)