4IRG
Uninhibited DNA-binding domain of the Ets transcription factor ERG
Summary for 4IRG
Entry DOI | 10.2210/pdb4irg/pdb |
Related | 4IRH 4IRI |
Descriptor | Transcriptional regulator ERG (2 entities in total) |
Functional Keywords | winged helix-turn-helix, ets domain, dna binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P11308 |
Total number of polymer chains | 1 |
Total formula weight | 12562.15 |
Authors | Regan, M.C.,Horanyi, P.S.,Pryor, E.E.,Sarver, J.L.,Cafiso, D.S.,Bushweller, J.H. (deposition date: 2013-01-14, release date: 2013-07-31, Last modification date: 2024-02-28) |
Primary citation | Regan, M.C.,Horanyi, P.S.,Pryor, E.E.,Sarver, J.L.,Cafiso, D.S.,Bushweller, J.H. Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited. Proc.Natl.Acad.Sci.USA, 110:13374-13379, 2013 Cited by PubMed: 23898196DOI: 10.1073/pnas.1301726110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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