4IQU

Tdt core in complex with inhibitor (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid

4IQU の概要

• エントリーDOI: 10.2210/pdb4iqu/pdb
• 関連するPDBエントリー: 4IQT 4IQV 4IQW
• 分子名称: DNA nucleotidylexotransferase, SODIUM ION, (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid, ... (4 entities in total)
• 機能のキーワード: terminal transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Isoform TDT-S: Nucleus. Isoform TDT-L: Cytoplasm. Nucleus : P09838
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46056.29

構造登録者

Gouge, J.,Delarue, M. (登録日: 2013-01-13, 公開日: 2013-09-04, 最終更新日: 2024-03-13)

• 主引用文献: Costi, R.,Cuzzucoli Crucitti, G.,Pescatori, L.,Messore, A.,Scipione, L.,Tortorella, S.,Amoroso, A.,Crespan, E.,Campiglia, P.,Maresca, B.,Porta, A.,Granata, I.,Novellino, E.,Gouge, J.,Delarue, M.,Maga, G.,Di Santo, R.; New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.; J.Med.Chem., 56:7431-7441, 2013; PubMed: 23968551; DOI: 10.1021/jm4010187

実験手法

X-RAY DIFFRACTION (2.4 Å)