4IPH

Structure of N-terminal domain of RPA70 in complex with VU079104 inhibitor

Summary for 4IPH

Entry DOI	10.2210/pdb4iph/pdb
Related	4IPC 4IPD 4IPG
Descriptor	Replication protein A 70 kDa DNA-binding subunit, ~{N}-(2,3-dimethylphenyl)-7-oxidanylidene-12-sulfanylidene-5,11-dithia-1,8-diazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,9-triene-10-carboxamide (3 entities in total)
Functional Keywords	ob-fold, protein binding, protein binding-inhibitor complex, protein binding/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	14272.73
Authors	Feldkamp, M.D.,Frank, A.O.,Vangamudi, B.,Fesik, S.W.,Chazin, W.J. (deposition date: 2013-01-09, release date: 2013-09-11, Last modification date: 2023-09-20)
Primary citation	Feldkamp, M.D.,Frank, A.O.,Kennedy, J.P.,Patrone, J.D.,Vangamudi, B.,Waterson, A.G.,Fesik, S.W.,Chazin, W.J. Surface Reengineering of RPA70N Enables Cocrystallization with an Inhibitor of the Replication Protein A Interaction Motif of ATR Interacting Protein. Biochemistry, 52:6515-6524, 2013 Cited by PubMed: 23962067 DOI: 10.1021/bi400542z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation