4IPH
Structure of N-terminal domain of RPA70 in complex with VU079104 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Replication protein A 70 kDa DNA-binding subunit | polymer | 123 | 13497.7 | 1 | UniProt (P27694) Pfam (PF04057) In PDB | Homo sapiens (human) | RP-A p70, Replication factor A protein 1, RF-A protein 1, Single-stranded DNA-binding protein |
| 2 | A | ~{N}-(2,3-dimethylphenyl)-7-oxidanylidene-12-sulfanylidene-5,11-dithia-1,8-diazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,9-triene-10-carboxamide | non-polymer | 387.5 | 2 | Chemie (1FJ) | |||
| 3 | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A: 1 - 120 (UniProt: P27694)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Arg 7 | Glu 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13497.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 775.0 | |
| All* | Total formula weight | 14272.7 |
