4IOC
Crystal structure of compound 4f bound to large ribosomal subunit (50S) from Deinococcus radiodurans
Summary for 4IOC
| Entry DOI | 10.2210/pdb4ioc/pdb |
| Related | 4IO9 4IOA |
| Descriptor | 23S ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (32 entities in total) |
| Functional Keywords | ribosome-ribosome inhibitor complex, ribosome/ribosome inhibitor |
| Biological source | Deinococcus radiodurans More |
| Total number of polymer chains | 30 |
| Total formula weight | 1365975.10 |
| Authors | Han, S.,Marr, E.S. (deposition date: 2013-01-07, release date: 2013-03-06, Last modification date: 2024-10-30) |
| Primary citation | Magee, T.V.,Han, S.,McCurdy, S.P.,Nguyen, T.T.,Granskog, K.,Marr, E.S.,Maguire, B.A.,Huband, M.D.,Chen, J.M.,Subashi, T.A.,Shanmugasundaram, V. Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. Bioorg.Med.Chem.Lett., 23:1727-1731, 2013 Cited by PubMed Abstract: A novel series of 3-O-carbamoyl erythromycin A derived analogs, labeled carbamolides, with activity versus resistant bacterial isolates of staphylococci (including macrolide and oxazolidinone resistant strains) and streptococci are reported. An (R)-2-aryl substituent on a pyrrolidine carbamate appeared to be critical for achieving potency against resistant strains. Crystal structures showed a distinct aromatic interaction between the (R)-2-aryl (3-pyridyl for 4d) substituent on the pyrrolidine and G2484 (G2505, Escherichia coli) of the Deinococcus radiodurans 50S ribosome (3.2Å resolution). PubMed: 23414806DOI: 10.1016/j.bmcl.2013.01.067 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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