4IO8

Crystal structure of human HSP70 complexed with 4-{(2R,3S,4R)-5-[(R)-6-Amino-8-(3,4-dichloro-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxymethyl}-benzonitrile

Summary for 4IO8

Entry DOI	10.2210/pdb4io8/pdb
Descriptor	Heat shock 70kDa protein 1A variant, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile (3 entities in total)
Functional Keywords	hsp70, atpase, molecular chaperone, chaperone
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42627.04
Authors	Musil, D.,Scholz, S. (deposition date: 2013-01-07, release date: 2013-12-18, Last modification date: 2023-09-20)
Primary citation	Schlecht, R.,Scholz, S.R.,Dahmen, H.,Wegener, A.,Sirrenberg, C.,Musil, D.,Bomke, J.,Eggenweiler, H.M.,Mayer, M.P.,Bukau, B. Functional analysis of hsp70 inhibitors. Plos One, 8:e78443-e78443, 2013 Cited by PubMed: 24265689 DOI: 10.1371/journal.pone.0078443 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.58 Å)

Structure validation