4IJP
Crystal Structure of Human PRPF4B kinase domain in complex with 4-{5-[(2-Chloro-pyridin-4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine
Summary for 4IJP
Entry DOI | 10.2210/pdb4ijp/pdb |
Related | 4IAN 4IFC 4IIR |
Descriptor | Serine/threonine-protein kinase PRP4 homolog, 4-(5-{[(2-chloropyridin-4-yl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q13523 |
Total number of polymer chains | 2 |
Total formula weight | 85299.17 |
Authors | Mechin, I.,Haas, K.,Chen, X.,Zhang, Y.,McLean, L. (deposition date: 2012-12-22, release date: 2013-08-28, Last modification date: 2024-10-16) |
Primary citation | Gao, Q.,Mechin, I.,Kothari, N.,Guo, Z.,Deng, G.,Haas, K.,McManus, J.,Hoffmann, D.,Wang, A.,Wiederschain, D.,Rocnik, J.,Czechtizky, W.,Chen, X.,McLean, L.,Arlt, H.,Harper, D.,Liu, F.,Majid, T.,Patel, V.,Lengauer, C.,Garcia-Echeverria, C.,Zhang, B.,Cheng, H.,Dorsch, M.,Huang, S.M. Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288:30125-30138, 2013 Cited by PubMed: 24003220DOI: 10.1074/jbc.M113.473348 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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