4IJP
Crystal Structure of Human PRPF4B kinase domain in complex with 4-{5-[(2-Chloro-pyridin-4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase PRP4 homolog | polymer | 358 | 41933.5 | 2 | UniProt (Q13523) Pfam (PF00069) In PDB | Homo sapiens (human) | PRP4 kinase, PRP4 pre-mRNA-processing factor 4 homolog |
2 | A, B | 4-(5-{[(2-chloropyridin-4-yl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide | non-polymer | 427.9 | 2 | Chemie (1EH) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
4 | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A, B: 657 - 1007 (UniProt: Q13523)
PDB | External Database | Details |
---|---|---|
Met 656 | - | expression tag |
His 1008 | - | expression tag |
His 1009 | - | expression tag |
His 1010 | - | expression tag |
His 1011 | - | expression tag |
His 1012 | - | expression tag |
His 1013 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 83866.9 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1432.2 | |
All* | Total formula weight | 85299.2 |