4IJH

Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A

Summary for 4IJH

• Entry DOI: 10.2210/pdb4ijh/pdb
• Related: 4IJL
• Descriptor: Replication protein A 70 kDa DNA-binding subunit, 3-chloro-6-[3-(4-fluorophenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]-1-benzothiophene-2-carboxylic acid (3 entities in total)
• Functional Keywords: ob-fold, protein-protein interaction, dna binding protein-inhibitor complex, dna binding protein/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P27694
• Total number of polymer chains: 1
• Total formula weight: 15527.00

Authors

Feldkamp, M.D.,Patrone, J.D.,Kennedy, J.P.,Frank, A.O.,Vangamudi, B.,Pelz, N.F.,Rossanese, O.W.,Waterson, A.G.,Fesik, S.W.,Chazin, W.J. (deposition date: 2012-12-21, release date: 2013-08-14, Last modification date: 2023-09-20)

• Primary citation: Patrone, J.D.,Kennedy, J.P.,Frank, A.O.,Feldkamp, M.D.,Vangamudi, B.,Pelz, N.F.,Rossanese, O.W.,Waterson, A.G.,Chazin, W.J.,Fesik, S.W.; Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.; ACS MED.CHEM.LETT., 4:601-605, 2013; PubMed: 23914285; DOI: 10.1021/ml400032y

Experimental method

X-RAY DIFFRACTION (1.498 Å)