4IJH
Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A
Summary for 4IJH
Entry DOI | 10.2210/pdb4ijh/pdb |
Related | 4IJL |
Descriptor | Replication protein A 70 kDa DNA-binding subunit, 3-chloro-6-[3-(4-fluorophenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]-1-benzothiophene-2-carboxylic acid (3 entities in total) |
Functional Keywords | ob-fold, protein-protein interaction, dna binding protein-inhibitor complex, dna binding protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P27694 |
Total number of polymer chains | 1 |
Total formula weight | 15527.00 |
Authors | Feldkamp, M.D.,Patrone, J.D.,Kennedy, J.P.,Frank, A.O.,Vangamudi, B.,Pelz, N.F.,Rossanese, O.W.,Waterson, A.G.,Fesik, S.W.,Chazin, W.J. (deposition date: 2012-12-21, release date: 2013-08-14, Last modification date: 2023-09-20) |
Primary citation | Patrone, J.D.,Kennedy, J.P.,Frank, A.O.,Feldkamp, M.D.,Vangamudi, B.,Pelz, N.F.,Rossanese, O.W.,Waterson, A.G.,Chazin, W.J.,Fesik, S.W. Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. ACS MED.CHEM.LETT., 4:601-605, 2013 Cited by PubMed: 23914285DOI: 10.1021/ml400032y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.498 Å) |
Structure validation
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