4IJ0
Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation
Summary for 4IJ0
Entry DOI | 10.2210/pdb4ij0/pdb |
Related | 4ITD |
Descriptor | DNA (5'-D(*CP*GP*CP*(C6G)P*AP*AP*TP*TP*CP*GP*CP*G)-3'), STRONTIUM ION, 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ... (4 entities in total) |
Functional Keywords | damaged dna, o6-carboxymethylguanine, mutagenesis, dna |
Total number of polymer chains | 2 |
Total formula weight | 8130.21 |
Authors | Zhang, F.,Suzuki, K.,Tsunoda, M.,Wilkinson, O.,Millington, C.L.,Williams, D.M.,Morishita, E.C.,Takenaka, A. (deposition date: 2012-12-20, release date: 2013-05-08, Last modification date: 2024-03-20) |
Primary citation | Zhang, F.,Tsunoda, M.,Suzuki, K.,Kikuchi, Y.,Wilkinson, O.,Millington, C.L.,Margison, G.P.,Williams, D.M.,Czarina Morishita, E.,Takenaka, A. Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations Nucleic Acids Res., 41:5524-5532, 2013 Cited by PubMed: 23580550DOI: 10.1093/nar/gkt198 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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