4IIR

Crystal Structure of AMPPNP-bound Human PRPF4B kinase domain

Summary for 4IIR

Entry DOI	10.2210/pdb4iir/pdb
Related	4IAN 4IFC 4IJP
Descriptor	Serine/threonine-protein kinase PRP4 homolog, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... (5 entities in total)
Functional Keywords	kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q13523
Total number of polymer chains	2
Total formula weight	85287.89
Authors	Mechin, I.,Haas, K.,Chen, X.,Zhang, Y.,McLean, L. (deposition date: 2012-12-20, release date: 2013-08-28, Last modification date: 2017-11-15)
Primary citation	Gao, Q.,Mechin, I.,Kothari, N.,Guo, Z.,Deng, G.,Haas, K.,McManus, J.,Hoffmann, D.,Wang, A.,Wiederschain, D.,Rocnik, J.,Czechtizky, W.,Chen, X.,McLean, L.,Arlt, H.,Harper, D.,Liu, F.,Majid, T.,Patel, V.,Lengauer, C.,Garcia-Echeverria, C.,Zhang, B.,Cheng, H.,Dorsch, M.,Huang, S.M. Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288:30125-30138, 2013 Cited by PubMed: 24003220 DOI: 10.1074/jbc.M113.473348 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation