4II5
Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION
Summary for 4II5
Entry DOI | 10.2210/pdb4ii5/pdb |
Related | 4I3Z |
Descriptor | Cyclin-dependent kinase 2, Cyclin-A2, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | adp and magnesium binding, t160 phosphorylation, transferase-cell cycle complex, transferase/cell cycle |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm, cytoskeleton, centrosome: P24941 Nucleus: P51943 |
Total number of polymer chains | 4 |
Total formula weight | 128764.83 |
Authors | Jacobsen, D.M.,Bao, Z.-Q.,O'Brien, P.J.,Brooks III, C.L.,Young, M.A. (deposition date: 2012-12-19, release date: 2013-01-23) |
Primary citation | Jacobsen, D.M.,Bao, Z.-Q.,O'Brien, P.J.,Brooks III, C.L.,Young, M.A. Price to be paid for two-metal catalysis: Magnesium ions that accelerate chemistry unavoidably limit product release from a PROTEIN KINASE J.Am.Chem.Soc., 134:15357-, 2012 Cited by PubMed: 22891849PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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