4IH7
Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds
4IH7 の概要
エントリーDOI | 10.2210/pdb4ih7/pdb |
関連するPDBエントリー | 4IH5 4IH6 |
分子名称 | RNA-directed RNA polymerase, ZINC ION, 3-(3-tert-butylphenyl)pyridin-2(1H)-one, ... (4 entities in total) |
機能のキーワード | fragment based drug design, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Hepatitis C virus (HCV) |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 127294.86 |
構造登録者 | |
主引用文献 | Talamas, F.X.,Ao-Ieong, G.,Brameld, K.A.,Chin, E.,de Vicente, J.,Dunn, J.P.,Ghate, M.,Giannetti, A.M.,Harris, S.F.,Labadie, S.S.,Leveque, V.,Li, J.,Lui, A.S.,McCaleb, K.L.,Najera, I.,Schoenfeld, R.C.,Wang, B.,Wong, A. De novo fragment design: a medicinal chemistry approach to fragment-based lead generation. J.Med.Chem., 56:3115-3119, 2013 Cited by PubMed: 23509929DOI: 10.1021/jm4002605 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.3 Å) |
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