4IGR

Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist ZA302

4IGR の概要

• エントリーDOI: 10.2210/pdb4igr/pdb
• 関連するPDBエントリー: 3S9E 4IGT
• 分子名称: Glutamate receptor, ionotropic kainate 3, (4R)-4-{3-[hydroxy(methyl)amino]-3-oxopropyl}-L-glutamic acid, POTASSIUM ION, ... (6 entities in total)
• 機能のキーワード: membrane protein, ionotropic glutamate receptor, kainate receptor, ligand-binding domain, agonist
• 由来する生物種: Rattus norvegicus (rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P42264
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29549.31

構造登録者

Larsen, A.P.,Venskutonyte, R.,Gajhede, M.,Kastrup, J.S.,Frydenvang, K. (登録日: 2012-12-18, 公開日: 2013-03-06, 最終更新日: 2023-11-08)

• 主引用文献: Assaf, Z.,Larsen, A.P.,Venskutonyte, R.,Han, L.,Abrahamsen, B.,Nielsen, B.,Gajhede, M.,Kastrup, J.S.,Jensen, A.A.,Pickering, D.S.,Frydenvang, K.,Gefflaut, T.,Bunch, L.; Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.; J.Med.Chem., 56:1614-1628, 2013; PubMed: 23414088; DOI: 10.1021/jm301433m

実験手法

X-RAY DIFFRACTION (2.65 Å)