4IGH

High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog

4IGH の概要

• エントリーDOI: 10.2210/pdb4igh/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
• 機能のキーワード: anti-viral, quinoline-4-carboxylic acid, redox, dehydrogenase, fmn, membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion inner membrane; Single-pass membrane protein: Q02127
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42143.88

構造登録者

Deng, X.,Das, P.,Fontoura, B.M.A.,Phillips, M.A.,De Brabander, J.K. (登録日: 2012-12-17, 公開日: 2013-08-21, 最終更新日: 2023-09-20)

• 主引用文献: Das, P.,Deng, X.,Zhang, L.,Roth, M.G.,Fontoura, B.M.,Phillips, M.A.,De Brabander, J.K.; SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity.; ACS MED.CHEM.LETT., 4:517-521, 2013; PubMed: 23930152; DOI: 10.1021/ml300464h

実験手法

X-RAY DIFFRACTION (1.3 Å)