4IFH
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619
Replaces: 4GSESummary for 4IFH
Entry DOI | 10.2210/pdb4ifh/pdb |
Descriptor | Insulin-degrading enzyme, ZINC ION, N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-4-methylbenzamide, ... (4 entities in total) |
Functional Keywords | insulin degrading enzyme, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14735 |
Total number of polymer chains | 2 |
Total formula weight | 229697.44 |
Authors | Liang, W.G.,Guo, Q.,Deprez, R.,Deprez, B.,Tang, W. (deposition date: 2012-12-14, release date: 2013-12-18, Last modification date: 2024-02-28) |
Primary citation | Deprez-Poulain, R.,Hennuyer, N.,Bosc, D.,Liang, W.G.,Enee, E.,Marechal, X.,Charton, J.,Totobenazara, J.,Berte, G.,Jahklal, J.,Verdelet, T.,Dumont, J.,Dassonneville, S.,Woitrain, E.,Gauriot, M.,Paquet, C.,Duplan, I.,Hermant, P.,Cantrelle, F.X.,Sevin, E.,Culot, M.,Landry, V.,Herledan, A.,Piveteau, C.,Lippens, G.,Leroux, F.,Tang, W.J.,van Endert, P.,Staels, B.,Deprez, B. Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun, 6:8250-8250, 2015 Cited by PubMed: 26394692DOI: 10.1038/ncomms9250 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.286 Å) |
Structure validation
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