4IE6

Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)

Summary for 4IE6

Entry DOI	10.2210/pdb4ie6/pdb
Related	3LFM 4IDZ 4IE0 4IE4 4IE5 4IE7
Descriptor	Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ... (4 entities in total)
Functional Keywords	double-stranded beta helix, jelly-roll motif, oxidoreductase, dioxygenase, nucleic acid demethylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q9C0B1
Total number of polymer chains	1
Total formula weight	57169.12
Authors	Aik, W.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2012-12-13, release date: 2013-04-03, Last modification date: 2023-11-08)
Primary citation	Aik, W.S.,Demetriades, M.,Hamdan, M.K.K.,Bagg, E.A.L.,Yeoh, K.K.,Lejeune, C.,Zhang, Z.,McDonough, M.A.,Schofield, C.J. Structural basis for inhibition of the fat mass and obesity associated protein (FTO) J.Med.Chem., 56:3680-3688, 2013 Cited by PubMed: 23547775 DOI: 10.1021/jm400193d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5036 Å)

Structure validation