4IE3

Crystal structure of human Arginase-2 complexed with inhbitor 1o

Summary for 4IE3

• Entry DOI: 10.2210/pdb4ie3/pdb
• Related: 1D3V 1PQ3
• Descriptor: Arginase-2, mitochondrial, MANGANESE (II) ION, BENZAMIDINE, ... (6 entities in total)
• Functional Keywords: metalloenzyme, alpha/beta fold, hydrolase, arginine metabolism, manganese, mitochondrion, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Mitochondrion : P78540
• Total number of polymer chains: 3
• Total formula weight: 101655.13

Authors

Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Beckett, P.,Van Zandt, M.C.,Ji, M.K.,Whitehouse, D.,Ryder, T.,Jagdmann, E.,Andreoli, M.,Mazur, A.,Padmanilayam, M.,Schroeter, H.,Golebiowski, A.,Podjarny, A. (deposition date: 2012-12-13, release date: 2013-03-20, Last modification date: 2023-09-20)

• Primary citation: Golebiowski, A.,Paul Beckett, R.,Van Zandt, M.,Ji, M.K.,Whitehouse, D.,Ryder, T.R.,Jagdmann, E.,Andreoli, M.,Mazur, A.,Padmanilayam, M.,Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Podjarny, A.,Schroeter, H.; 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.; Bioorg.Med.Chem.Lett., 23:2027-2030, 2013; PubMed: 23453840; DOI: 10.1016/j.bmcl.2013.02.024

Experimental method

X-RAY DIFFRACTION (2.3522 Å)