4IE0

Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with pyridine-2,4-dicarboxylate (2,4-PDCA)

4IE0 の概要

• エントリーDOI: 10.2210/pdb4ie0/pdb
• 関連するPDBエントリー: 3LFM 4IDZ 4IE4 4IE5 4IE6 4IE7
• 分子名称: Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: double-stranded beta helix, jelly-roll motif, oxidoreductase, dioxygenase, nucleic acid demethylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q9C0B1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57147.67

構造登録者

Aik, W.S.,McDonough, M.A.,Schofield, C.J. (登録日: 2012-12-13, 公開日: 2013-04-03, 最終更新日: 2023-11-08)

• 主引用文献: Aik, W.S.,Demetriades, M.,Hamdan, M.K.K.,Bagg, E.A.L.,Yeoh, K.K.,Lejeune, C.,Zhang, Z.,McDonough, M.A.,Schofield, C.J.; Structural basis for inhibition of the fat mass and obesity associated protein (FTO); J.Med.Chem., 56:3680-3688, 2013; PubMed: 23547775; DOI: 10.1021/jm400193d

実験手法

X-RAY DIFFRACTION (2.53 Å)