4IDT
Crystal Structure of NIK with 11-bromo-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine (T28)
Summary for 4IDT
Entry DOI | 10.2210/pdb4idt/pdb |
Related | 4IDV |
Descriptor | Mitogen-activated protein kinase kinase kinase 14, 11-bromo-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine (3 entities in total) |
Functional Keywords | nik, nuclear factor (nf)-kb, p100 processing, 2-aminopyrimidine, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q99558 |
Total number of polymer chains | 2 |
Total formula weight | 79005.82 |
Authors | |
Primary citation | Li, K.,McGee, L.R.,Fisher, B.,Sudom, A.,Liu, J.,Rubenstein, S.M.,Anwer, M.K.,Cushing, T.D.,Shin, Y.,Ayres, M.,Lee, F.,Eksterowicz, J.,Faulder, P.,Waszkowycz, B.,Plotnikova, O.,Farrelly, E.,Xiao, S.H.,Chen, G.,Wang, Z. Inhibiting NF-KB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure activity relationship, and co-crystal structures Bioorg.Med.Chem.Lett., 23:1238-1244, 2013 Cited by PubMed: 23374866DOI: 10.1016/j.bmcl.2013.01.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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