4ID7

ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol

4ID7 の概要

• エントリーDOI: 10.2210/pdb4id7/pdb
• 分子名称: Activated CDC42 kinase 1, cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane: Q07912
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31693.57

構造登録者

Jin, M.,Wang, J.,Kleinberg, A.,Kadalbajoo, M.,Siu, K.,Cooke, A.,Bittner, M.,Yao, Y.,Thelemann, A.,Ji, Q.,Bhagwat, S.,Crew, A.P.,Pachter, J.,Epstein, D.,Mulvihill, M.J. (登録日: 2012-12-11, 公開日: 2013-01-30, 最終更新日: 2024-02-28)

• 主引用文献: Jin, M.,Wang, J.,Kleinberg, A.,Kadalbajoo, M.,Siu, K.W.,Cooke, A.,Bittner, M.A.,Yao, Y.,Thelemann, A.,Ji, Q.,Bhagwat, S.,Mulvihill, K.M.,Rechka, J.A.,Pachter, J.A.,Crew, A.P.,Epstein, D.,Mulvihill, M.J.; Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors.; Bioorg.Med.Chem.Lett., 23:979-984, 2013; PubMed: 23317569; DOI: 10.1016/j.bmcl.2012.12.042

実験手法

X-RAY DIFFRACTION (3 Å)