Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target)

Summary for 4IAQ

DescriptorChimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Dihydroergotamine (3 entities in total)
Functional Keywordsdihydroergotamine, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, signaling protein, electron transport, gpcr dock
Biological sourceHomo sapiens
Cellular locationCell membrane ; Multi-pass membrane protein  P28222
Total number of polymer chains1
Total molecular weight46100.71
Primary citation
Wang, C.,Jiang, Y.,Ma, J.,Wu, H.,Wacker, D.,Katritch, V.,Han, G.W.,Liu, W.,Huang, X.P.,Vardy, E.,McCorvy, J.D.,Gao, X.,Zhou, X.E.,Melcher, K.,Zhang, C.,Bai, F.,Yang, H.,Yang, L.,Jiang, H.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,Xu, H.E.
Structural basis for molecular recognition at serotonin receptors.
Science, 340:610-614, 2013
PubMed: 23519210 (PDB entries with the same primary citation)
DOI: 10.1126/science.1232807
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.29260.3%9.3%6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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