4IAQ
Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target)
Summary for 4IAQ
Entry DOI | 10.2210/pdb4iaq/pdb |
Related | 4IAR |
Descriptor | Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Dihydroergotamine (3 entities in total) |
Functional Keywords | dihydroergotamine, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, signaling protein, electron transport, gpcr dock |
Biological source | Homo sapiens More |
Cellular location | Cell membrane ; Multi-pass membrane protein : P28222 |
Total number of polymer chains | 1 |
Total formula weight | 46100.71 |
Authors | Wang, C.,Jiang, Y.,Ma, J.,Wu, H.,Wacker, D.,Katritch, V.,Han, G.W.,Liu, W.,Huang, X.,Vardy, E.,McCorvy, J.D.,Gao, X.,Zhou, E.X.,Melcher, K.,Zhang, C.,Bai, F.,Yang, H.,Yang, L.,Jiang, H.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,Xu, H.E.,GPCR Network (GPCR) (deposition date: 2012-12-07, release date: 2013-03-13, Last modification date: 2023-09-20) |
Primary citation | Wang, C.,Jiang, Y.,Ma, J.,Wu, H.,Wacker, D.,Katritch, V.,Han, G.W.,Liu, W.,Huang, X.P.,Vardy, E.,McCorvy, J.D.,Gao, X.,Zhou, X.E.,Melcher, K.,Zhang, C.,Bai, F.,Yang, H.,Yang, L.,Jiang, H.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,Xu, H.E. Structural basis for molecular recognition at serotonin receptors. Science, 340:610-614, 2013 Cited by PubMed: 23519210DOI: 10.1126/science.1232807 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report