4IAE

Crystal structure of BAY 60-2770 bound to nostoc H-NOX domain

Summary for 4IAE

Entry DOI	10.2210/pdb4iae/pdb
Related	2O09 2O0C 2O0G 3L6J 4IAH 4IAM
Descriptor	Alr2278 protein, 4-({(4-carboxybutyl)[2-(5-fluoro-2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}methyl)benzoic acid, MALONATE ION, ... (4 entities in total)
Functional Keywords	activation, hnox domain, heme binding, no binding, lyase
Biological source	Nostoc sp.
Total number of polymer chains	2
Total formula weight	43916.56
Authors	Kumar, V.,van den Akker, F.,Martin, F. (deposition date: 2012-12-06, release date: 2013-11-20, Last modification date: 2023-09-20)
Primary citation	Kumar, V.,Martin, F.,Hahn, M.G.,Schaefer, M.,Stamler, J.S.,Stasch, J.P.,van den Akker, F. Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes. Biochemistry, 52:3601-3608, 2013 Cited by PubMed: 23614626 DOI: 10.1021/bi301657w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation