4IAE
Crystal structure of BAY 60-2770 bound to nostoc H-NOX domain
Summary for 4IAE
Entry DOI | 10.2210/pdb4iae/pdb |
Related | 2O09 2O0C 2O0G 3L6J 4IAH 4IAM |
Descriptor | Alr2278 protein, 4-({(4-carboxybutyl)[2-(5-fluoro-2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}methyl)benzoic acid, MALONATE ION, ... (4 entities in total) |
Functional Keywords | activation, hnox domain, heme binding, no binding, lyase |
Biological source | Nostoc sp. |
Total number of polymer chains | 2 |
Total formula weight | 43916.56 |
Authors | Kumar, V.,van den Akker, F.,Martin, F. (deposition date: 2012-12-06, release date: 2013-11-20, Last modification date: 2023-09-20) |
Primary citation | Kumar, V.,Martin, F.,Hahn, M.G.,Schaefer, M.,Stamler, J.S.,Stasch, J.P.,van den Akker, F. Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes. Biochemistry, 52:3601-3608, 2013 Cited by PubMed: 23614626DOI: 10.1021/bi301657w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
Download full validation report