4I8N

CRYSTAL STRUCTURE of PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN INHIBITOR [(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL)SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID

Summary for 4I8N

• Entry DOI: 10.2210/pdb4i8n/pdb
• Related: 2VEU
• Descriptor: Tyrosine-protein phosphatase non-receptor type 1, [(4-{(2S)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid (3 entities in total)
• Functional Keywords: protein phosphatase, ptp1b, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• Total number of polymer chains: 1
• Total formula weight: 41287.92

Authors

Reddy, S.M.V.V.V.,Rao, K.N.,Subramanya, H. (deposition date: 2012-12-03, release date: 2012-12-26, Last modification date: 2024-02-28)

• Primary citation: Reddy, M.V.,Ghadiyaram, C.,Panigrahi, S.K.,Krishnamurthy, N.R.,Hosahalli, S.,Chandrasekharappa, A.P.,Manna, D.,Badiger, S.E.,Dubey, P.K.,Mangamoori, L.N.; X-Ray Structure of PTP1B in Complex with a New PTP1B Inhibitor.; Protein Pept.Lett., 21:90-93, 2014; PubMed: 23964742

Experimental method

X-RAY DIFFRACTION (2.5 Å)