4I7F

HIV-1 Reverse Transcriptase in complex with a phosphonate analog of nevirapine

Summary for 4I7F
DescriptorReverse transcriptase, diethyl ({4-[2-(11-ethyl-5-methyl-6-oxo-6,11-dihydro-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-8-yl)ethyl]phenoxy}methyl)phosphonate, SULFATE ION, ... (7 entities in total)
Functional Keywordsnnrti, hiv, reverse transcriptase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHIV-1 M:B_HXB2R (HIV-1)
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
Total number of polymer chains2
Total formula weight116966.01
Authors
Lansdon, E.B.,Parrish, J. (deposition date: 2012-11-30, release date: 2013-02-20, Last modification date: 2017-11-15)
Primary citationCannizzaro, C.,Chen, X.,Desai, M.C.,Lansdon, E.B.,Parrish, J.,Tong, L.,Wang, M.,Xu, L.,Zheng, X.
Synthesis and biological evaluation of phosphonate analogues of nevirapine.
Bioorg.Med.Chem.Lett., 23:1493-1497, 2013
PubMed: 23375792
DOI: 110.1016/j.bmcl.2012.12.049
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation
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PDB entries from 2021-06-09