4I79

Crystal structure of human NUP43

4I79 の概要

• エントリーDOI: 10.2210/pdb4i79/pdb
• 分子名称: Nucleoporin Nup43, floating chain, unknown sequence, UNKNOWN ATOM OR ION, ... (4 entities in total)
• 機能のキーワード: structural genomics consortium, sgc, wd40 repeat, cell cycle
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Chromosome, centromere, kinetochore: Q8NFH3
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 89241.68

構造登録者

Xu, C.,Tempel, W.,Li, Z.,He, H.,Wernimont, A.K.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (登録日: 2012-11-30, 公開日: 2013-02-27, 最終更新日: 2023-09-20)

主引用文献

Xu, C.,Li, Z.,He, H.,Seitova, A.,Wernimont, A.,Li, Y.,Loppnau, P.,Min, J.
Crystal structure of human nuclear pore complex component NUP43.
Febs Lett., 589:3247-3253, 2015

PubMed Abstract: Nuclear pore complexes (NPC) form nuclear pores that cross the nuclear envelope and allow molecules to transport between the nucleus and the cytoplasm. We solved the crystal structure of human Nup43 (hNUP43), an important component in the Nup107 subcomplex of NPC. hNup43 adopts a seven-bladed β-propeller fold. We confirmed by ITC that neither human Nup37 (hNup37) nor human Nup133 (hNup133) interacts with hNup43. We demonstrated by analytical gel filtration that the human Nup85-Seh1L binary complex recruits hNup43 to form a ternary complex. Based on amino acid sequence analysis, we predicted the hNup85-hSeh1L binding surface of hNup43.

PubMed: 26391640
DOI: 10.1016/j.febslet.2015.09.008

実験手法

X-RAY DIFFRACTION (1.75 Å)