4I6Q
JAK3 kinase domain in complex with 2-Phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1-cyclopropyl-ethyl)-amide
Summary for 4I6Q
Entry DOI | 10.2210/pdb4i6q/pdb |
Descriptor | Tyrosine-protein kinase JAK3, 1-phenylurea, N-[(1S)-1-cyclopropylethyl]-2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, ... (4 entities in total) |
Functional Keywords | kinase-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system; Peripheral membrane protein (By similarity): P52333 |
Total number of polymer chains | 1 |
Total formula weight | 36072.11 |
Authors | Kuglstatter, A.,Shao, A. (deposition date: 2012-11-30, release date: 2013-10-16, Last modification date: 2023-09-20) |
Primary citation | Jaime-Figueroa, S.,De Vicente, J.,Hermann, J.,Jahangir, A.,Jin, S.,Kuglstatter, A.,Lynch, S.M.,Menke, J.,Niu, L.,Patel, V.,Shao, A.,Soth, M.,Vu, M.D.,Yee, C. Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors. Bioorg.Med.Chem.Lett., 23:2522-2526, 2013 Cited by PubMed: 23541670DOI: 10.1016/j.bmcl.2013.03.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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