4I6Q

JAK3 kinase domain in complex with 2-Phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1-cyclopropyl-ethyl)-amide

Summary for 4I6Q

• Entry DOI: 10.2210/pdb4i6q/pdb
• Descriptor: Tyrosine-protein kinase JAK3, 1-phenylurea, N-[(1S)-1-cyclopropylethyl]-2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, ... (4 entities in total)
• Functional Keywords: kinase-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Endomembrane system; Peripheral membrane protein (By similarity): P52333
• Total number of polymer chains: 1
• Total formula weight: 36072.11

Authors

Kuglstatter, A.,Shao, A. (deposition date: 2012-11-30, release date: 2013-10-16, Last modification date: 2023-09-20)

Primary citation

Jaime-Figueroa, S.,De Vicente, J.,Hermann, J.,Jahangir, A.,Jin, S.,Kuglstatter, A.,Lynch, S.M.,Menke, J.,Niu, L.,Patel, V.,Shao, A.,Soth, M.,Vu, M.D.,Yee, C.
Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors.
Bioorg.Med.Chem.Lett., 23:2522-2526, 2013

PubMed Abstract: We report the discovery of a novel series of ATP-competitive Janus kinase 3 (JAK3) inhibitors based on the 5H-pyrrolo[2,3-b]pyrazine scaffold. The initial leads in this series, compounds 1a and 1h, showed promising potencies, but a lack of selectivity against other isoforms in the JAK family. Computational and crystallographic analysis suggested that the phenyl ether moiety possessed a favorable vector to achieve selectivity. Exploration of this vector resulted in the identification of 12b and 12d, as potent JAK3 inhibitors, demonstrating improved JAK family and kinase selectivity.

PubMed: 23541670
DOI: 10.1016/j.bmcl.2013.03.015

Experimental method

X-RAY DIFFRACTION (1.85 Å)