4I6L

Crystal structure of OTUB1 in complex with ubiquitin variant

4I6L の概要

• エントリーDOI: 10.2210/pdb4i6l/pdb
• 分子名称: Ubiquitin thioesterase OTUB1, Ubiquitin (3 entities in total)
• 機能のキーワード: deubiquitinase, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm (By similarity): Q96FW1; Ubiquitin: Cytoplasm (By similarity): P0CG48
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35332.88

構造登録者

Juang, Y.C.,Sicheri, F. (登録日: 2012-11-29, 公開日: 2013-01-16, 最終更新日: 2023-09-20)

• 主引用文献: Ernst, A.,Avvakumov, G.,Tong, J.,Fan, Y.,Zhao, Y.,Alberts, P.,Persaud, A.,Walker, J.R.,Neculai, A.M.,Neculai, D.,Vorobyov, A.,Garg, P.,Beatty, L.,Chan, P.K.,Juang, Y.C.,Landry, M.C.,Yeh, C.,Zeqiraj, E.,Karamboulas, K.,Allali-Hassani, A.,Vedadi, M.,Tyers, M.,Moffat, J.,Sicheri, F.,Pelletier, L.,Durocher, D.,Raught, B.,Rotin, D.,Yang, J.,Moran, M.F.,Dhe-Paganon, S.,Sidhu, S.S.; A strategy for modulation of enzymes in the ubiquitin system.; Science, 339:590-595, 2013; PubMed: 23287719; DOI: 10.1126/science.1230161

実験手法

X-RAY DIFFRACTION (2.488 Å)