4I41

Crystal Structure of human Ser/Thr kinase Pim1 in complex with mitoxantrone

4I41 の概要

• エントリーDOI: 10.2210/pdb4i41/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE (3 entities in total)
• 機能のキーワード: ser/thr kinase, mitoxantrone, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33426.83

構造登録者

Zhang, W.,Wan, X.,Xie, Y.,Huang, N. (登録日: 2012-11-27, 公開日: 2013-12-11, 最終更新日: 2019-07-17)

• 主引用文献: Wan, X.,Zhang, W.,Li, L.,Xie, Y.,Li, W.,Huang, N.; A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling.; J. Med. Chem., 56:2619-2629, 2013; PubMed: 23442188; DOI: 10.1021/jm400045y

実験手法

X-RAY DIFFRACTION (2.7 Å)