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4I3K

Crystal structure of a metabolic reductase with 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one

Summary for 4I3K
Entry DOI10.2210/pdb4i3k/pdb
Related3MAP
DescriptorIsocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (4 entities in total)
Functional Keywordsisocitrate dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight95508.69
Authors
Zheng, B.,Yao, Y.,Liu, Z.,Deng, L.,Anglin, J.L.,Jiang, H.,Prasad, B.V.V.,Song, Y. (deposition date: 2012-11-26, release date: 2013-05-22, Last modification date: 2024-02-28)
Primary citationZheng, B.,Yao, Y.,Liu, Z.,Deng, L.,Anglin, J.L.,Jiang, H.,Prasad, B.V.,Song, Y.
Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.
ACS Med Chem Lett, 4:542-546, 2013
Cited by
PubMed: 23795241
DOI: 10.1021/ml400036z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.3056 Å)
Structure validation

217705

数据于2024-03-27公开中

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