4I3K
Crystal structure of a metabolic reductase with 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isocitrate dehydrogenase [NADP] cytoplasmic | polymer | 414 | 46701.2 | 2 | UniProt (O75874) Pfam (PF00180) | Homo sapiens (human) | IDH, Cytosolic NADP-isocitrate dehydrogenase, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase |
| 2 | C, H (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D, E, F, I (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G (A) | 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one | non-polymer | 231.2 | 1 | Chemie (1BX) |
Sequence modifications
A, B: 1 - 414 (UniProt: O75874)
| PDB | External Database | Details |
|---|---|---|
| His 132 | Arg 132 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93402.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2106.3 | |
| All* | Total formula weight | 95508.7 |
