4I3K

Crystal structure of a metabolic reductase with 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one

4I3K の概要

• エントリーDOI: 10.2210/pdb4i3k/pdb
• 関連するPDBエントリー: 3MAP
• 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: isocitrate dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95508.69

構造登録者

Zheng, B.,Yao, Y.,Liu, Z.,Deng, L.,Anglin, J.L.,Jiang, H.,Prasad, B.V.V.,Song, Y. (登録日: 2012-11-26, 公開日: 2013-05-22, 最終更新日: 2024-02-28)

• 主引用文献: Zheng, B.,Yao, Y.,Liu, Z.,Deng, L.,Anglin, J.L.,Jiang, H.,Prasad, B.V.,Song, Y.; Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.; ACS Med Chem Lett, 4:542-546, 2013; PubMed: 23795241; DOI: 10.1021/ml400036z

実験手法

X-RAY DIFFRACTION (3.3056 Å)