4I22
Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib
Summary for 4I22
Entry DOI | 10.2210/pdb4i22/pdb |
Related | 4I1Z 4I20 4I21 4I23 4I24 |
Descriptor | Epidermal growth factor receptor, Gefitinib, SULFATE ION, ... (4 entities in total) |
Functional Keywords | kinase domain, phosphotrasfer, atp binding, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 38219.48 |
Authors | Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Stewart, A. (deposition date: 2012-11-21, release date: 2013-01-16, Last modification date: 2024-03-27) |
Primary citation | Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Weinrich, S.,Kath, J.C.,Stewart, A. Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21:209-219, 2013 Cited by PubMed: 23273428DOI: 10.1016/j.str.2012.11.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.71 Å) |
Structure validation
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