4I00

Crystal structure of influenza A neuraminidase N3-H274Y complexed with zanamivir

4I00 の概要

• エントリーDOI: 10.2210/pdb4i00/pdb
• 関連するPDBエントリー: 3CKZ 4HZV 4HZW 4HZX 4HZY 4IZZ
• 分子名称: Neuraminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: neuraminidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Influenza A virus
• 細胞内の位置: Host apical cell membrane ; Single-pass type II membrane protein : A9YN63
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44906.26

構造登録者

Li, Q.,Qi, J.,Vavricka, C.J.,Gao, G.F. (登録日: 2012-11-16, 公開日: 2013-11-13, 最終更新日: 2023-11-08)

• 主引用文献: Li, Q.,Qi, J.,Wu, Y.,Kiyota, H.,Tanaka, K.,Suhara, Y.,Ohrui, H.,Suzuki, Y.,Vavricka, C.J.,Gao, G.F.; Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.; J.Virol., 87:10016-10024, 2013; PubMed: 23824808; DOI: 10.1128/JVI.01129-13

実験手法

X-RAY DIFFRACTION (1.6 Å)