4HZZ

Crystal structure of influenza neuraminidase N3-H274Y complexed with oseltamivir

4HZZ の概要

関連するPDBエントリー3CL0 4HZV 4HZW 4HZX 4HZY 4I00
分子名称Neuraminidase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ... (6 entities in total)
機能のキーワードneuraminidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Influenza A virus
ポリマー鎖数1
分子量合計44783.19
構造登録者
Li, Q.,Qi, J.,Vavricka, C.J.,Gao, G.F. (登録日: 2012-11-16, 公開日: 2013-11-06)
主引用文献
Li, Q.,Qi, J.,Wu, Y.,Kiyota, H.,Tanaka, K.,Suhara, Y.,Ohrui, H.,Suzuki, Y.,Vavricka, C.J.,Gao, G.F.
Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.
J.Virol., 87:10016-10024, 2013
PubMed: 23824808 (主引用文献が同じPDBエントリー)
DOI: 10.1128/JVI.01129-13
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.601 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.16340.5%1.8%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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