4HZM
Crystal structure of Salmonella typhimurium family 3 glycoside hydrolase (NagZ) bound to N-[(3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]butanamide
Summary for 4HZM
Entry DOI | 10.2210/pdb4hzm/pdb |
Related | 4GVF 4GVG 4GVH 4GVI |
Descriptor | Beta-hexosaminidase, N-[(3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]butanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | tim-barrel, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Salmonella enterica subsp. enterica serovar Typhimurium |
Cellular location | Cytoplasm (By similarity): Q8ZQ06 |
Total number of polymer chains | 2 |
Total formula weight | 78107.66 |
Authors | Bacik, J.P.,Mark, B.L. (deposition date: 2012-11-15, release date: 2013-06-19, Last modification date: 2023-09-20) |
Primary citation | Stubbs, K.A.,Bacik, J.P.,Perley-Robertson, G.E.,Whitworth, G.E.,Gloster, T.M.,Vocadlo, D.J.,Mark, B.L. The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to beta-Lactams. Chembiochem, 14:1973-1981, 2013 Cited by PubMed: 24009110DOI: 10.1002/cbic.201300395 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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