4HZM

Crystal structure of Salmonella typhimurium family 3 glycoside hydrolase (NagZ) bound to N-[(3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]butanamide

4HZM の概要

• エントリーDOI: 10.2210/pdb4hzm/pdb
• 関連するPDBエントリー: 4GVF 4GVG 4GVH 4GVI
• 分子名称: Beta-hexosaminidase, N-[(3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]butanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: tim-barrel, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Salmonella enterica subsp. enterica serovar Typhimurium
• 細胞内の位置: Cytoplasm (By similarity): Q8ZQ06
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78107.66

構造登録者

Bacik, J.P.,Mark, B.L. (登録日: 2012-11-15, 公開日: 2013-06-19, 最終更新日: 2023-09-20)

• 主引用文献: Stubbs, K.A.,Bacik, J.P.,Perley-Robertson, G.E.,Whitworth, G.E.,Gloster, T.M.,Vocadlo, D.J.,Mark, B.L.; The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to beta-Lactams.; Chembiochem, 14:1973-1981, 2013; PubMed: 24009110; DOI: 10.1002/cbic.201300395

実験手法

X-RAY DIFFRACTION (1.45 Å)