4HYI

X-RAY Crystal structure of compound 40 bound to human chk1 kinase domain

Summary for 4HYI

Entry DOI	10.2210/pdb4hyi/pdb
Related	4HYH
Descriptor	Serine/threonine-protein kinase Chk1, GLYCEROL, 2-(1H-indazol-1-yl)-N-[2-(piperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide, ... (4 entities in total)
Functional Keywords	serine/threonine-protein kinase chk1 inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O14757
Total number of polymer chains	1
Total formula weight	33723.76
Authors	Fischmann, T.O. (deposition date: 2012-11-13, release date: 2013-03-06, Last modification date: 2024-02-28)
Primary citation	Huang, X.,Cheng, C.C.,Fischmann, T.O.,Duca, J.S.,Richards, M.,Tadikonda, P.K.,Reddy, P.A.,Zhao, L.,Arshad Siddiqui, M.,Parry, D.,Davis, N.,Seghezzi, W.,Wiswell, D.,Shipps, G.W. Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors. Bioorg.Med.Chem.Lett., 23:2590-2594, 2013 Cited by PubMed: 23535330 DOI: 10.1016/j.bmcl.2013.02.108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.399 Å)

Structure validation